An evaluation of nebulised amphotericin B deoxycholate (Fungizone ® ) for treatment of pulmonary aspergillosis in the UK National Aspergillosis Centre
نویسندگان
چکیده
منابع مشابه
The Management of Chronic Pulmonary Aspergillosis: The UK National Aspergillosis Centre Approach
Purpose of Review Chronic pulmonary aspergillosis (CPA) is a serious long-term fungal disease of the lung with a worldwide prevalence. Treatment of CPA is not straightforward given the often-multiple associated co-morbidities, complex clinical picture, drug interactions, toxicities and intolerances. Recent Findings First line treatment is oral itraconazole or voriconazole. In the event of int...
متن کاملNebulised amphotericin B-polymethacrylic acid nanoparticle prophylaxis prevents invasive aspergillosis
UNLABELLED Aspergillus species are the major life threatening fungal pathogens in transplant patients. Germination of inhaled fungal spores initiates infection, causes severe pneumonia, and has a mortality of >50%. This is leading to the consideration of pre-exposure prophylaxis to prevent infection. We made a very low MWt amphotericin B-polymethacrylic acid nanoparticle. It was not toxic to lu...
متن کاملPharmacokinetics and pharmacodynamics of amphotericin B deoxycholate, liposomal amphotericin B, and amphotericin B lipid complex in an in vitro model of invasive pulmonary aspergillosis.
The pharmacodynamic and pharmacokinetic (PK-PD) properties of amphotericin B (AmB) formulations against invasive pulmonary aspergillosis (IPA) are not well understood. We used an in vitro model of IPA to further elucidate the PK-PD of amphotericin B deoxycholate (DAmB), liposomal amphotericin B (LAmB) and amphotericin B lipid complex (ABLC). The pharmacokinetics of these formulations for endova...
متن کاملAn economic evaluation of voriconazole versus amphotericin B for the treatment of invasive aspergillosis in Canada
Health technology The study compared the use of voriconazole and conventional amphotericin B deoxycholate (CAB). Voriconazole was administered at a dose of 6 mg/kg intravenously (IV) twice a day on day 1, followed by 4 mg/kg IV twice a day for at least 7 days, at which time patients could switch to oral voriconazole 200 mg twice daily. CAB was administered at a dose of 1.0 to 1.5 mg/kg IV once ...
متن کاملAn economic evaluation of voriconazole versus amphotericin B for the treatment of invasive aspergillosis in Canada.
BACKGROUND Invasive aspergillosis (IA) is a serious fungal infection that affects immunocompromised patients. The Global Comparative Aspergillosis study demonstrated that voriconazole, a new broad-spectrum triazole, had better responses and improved survival compared with conventional amphotericin B deoxycholate (CAB) and other licensed antifungal therapy (OLAT) for the treatment of definite or...
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ژورنال
عنوان ژورنال: Mycoses
سال: 2019
ISSN: 0933-7407,1439-0507
DOI: 10.1111/myc.12996